Drug Listing:

Drug Listing: Autonomic Pharmacology

Direct Muscarinic Agonists
- Choline Esters
- Alkaloids
Direct Nicotinic Agonist
Acetylcholinesterase Inhibitor (Reversible)
Acetylcholinesterase Inhibitor (Irreversible)
Muscarinic Antagonist
2-PAM
Ganglionic Blockers

Catecholamines
Direct Adrenoceptor Agonists
Indirect-Acting Sympathomimetics
Alpha adrenoceptor Antagonists
Beta-adrenoceptor Antagonists
Adrenergic Neuron Blocking Drugs

**Direct Muscarinic Agonists**
Choline Esters Acetylcholine Bethanechol (Urecholine) Carbachol Methacholine (Provocholine) Return to top Menu	Alkaloids Muscarine Pilocarpine (Pilocar)

**Direct Nicotinic Agonist**
Nicotine Return to top Menu

Acetylcholinesterase Inhibitors
Acetylcholinesterase Inhibitors ("Reversible") Neostigmine (Prostigmin) Physostigmine (Antilirium) Edrophonium (Tensilon) Return to top Menu	Acetylcholinesterase Inhibitors ("Irreversible") Soman Parathion Malathion Isoflurophate (Floropryl) (Diisopropylflurorphosphate DFP) Echothiophate (Phospholine)

**Muscarinic Antagonists**
Atropine Scopolamine Ipratropium (Atrovent) Pirenzepine (M₁ selective) Return to top Menu

**2-PAM: Acetylcholinesterase Reactivator**
Pralidoxime (Protopam) {2-PAM}:peripheral acetylcholinesterase reactivator for certain phosphoryl-enzyme complexes Return to top Menu

**Ganglionic Blockers**
Mecamylamine (Inversine) Hexamethonium Trimethaphan Return to top Menu

Catecholamines
DRUG Epinephrine Norepinephrine (Levophed) Isoproterenol (Isuprel) Dobutamine (Dobutrex) Dopamine (Intropin) Return to top Menu	Receptor Classification alpha-1, alpha-2, beta-1, beta-2 alpha-1, alpha-2, beta-1 beta-1, beta-2 beta-1 (alpha-1) D-1 (alpha-1 and beta-1 at high doses)

Direct Adrenoceptor Agonists
Drug Phenylephrine (Neo-Synephrine) Methoxamine (Vasoxyl) Oxymetazoline (Afrin) Clonidine (Catapres) Ritodrine (Yutopar) Terbutaline (Brethine) Albuterol (Ventolin,Proventil) Salmeterol (Serevent) Return to top Menu	Receptor Classification alpha-1 alpha-1 alpha-1, alpha-2 alpha-2 beta-2 beta-2 beta-2 beta-2

**Indirect-Acting Sympathomimetics**
Drug Ephedrine, Pseudoephedrine Cocaine Tyramine Amphetamine Return to top Menu	Mechanism of Action Release & direct receptor activation Uptake I inhibitor Release similar to ephedrine, but greater CNS actions

**Alpha-Adrenoceptor Antagonists**
Drug Prazosin (Minipress) Terazosin (Hytrin) Trimazosin Doxazosin (Cardura) Phentolamine (Regitine) Phenoxybenzamine (Dibenzyline) Tolazoline (Priscoline) Labetalol (Trandate, Normodyne) Yohimbine (Yocon) Return to top Menu	Receptor Selectivity(alpha₁ vs. alpha₂) alpha-1 alpha-1 alpha-1 alpha-1 non-selective only slightly selective for alpha-1 (non-competitive) non-selective alpha-1 (also non-selective beta-antagonist) alpha-2

ß-Adrenoceptor antagonists
Drug Propranolol (Inderal) Metoprolol (Lopressor) Esmolol (Brevibloc) Atenolol (Tenormin) Nadolol (Corgard) Timolol (Blocadren) Pindolol (Visken) Labetalol (Trandate, Normodyne) Butoxamine Return to top Menu	Receptor Selectivity non-selective beta-1 beta-1 beta-1 non-selective non-selective non-selective (partial agonist) non-selective (selective alpha-1-antagonist) beta-2 (no clinical applications)

Adrenergic Neuron Blocking Drugs
Reserpine Guanethidine (Ismelin) Return to top Menu	*non-selective blockade of vesicular* uptake and storage of biogenic amines similar to reserpine: Uptake I dependent**