Dedication

About the authors

Preface

Tools and Techniques

Clinical Applications

Molecular Evolution

Supplements Supporting Biochemistry, Fifth Edition

Acknowledgments

I. The Molecular Design of Life

1. Prelude: Biochemistry and the Genomic Revolution

2. Biochemical Evolution

3. Protein Structure and Function

4. Exploring Proteins

5. DNA, RNA, and the Flow of Genetic Information

6. Exploring Genes

7. Exploring Evolution

8. Enzymes: Basic Concepts and Kinetics

9. Catalytic Strategies

10. Regulatory Strategies: Enzymes and Hemoglobin

11. Carbohydrates

12. Lipids and Cell Membranes

13. Membrane Channels and Pumps

II. Transducing and Storing Energy

14. Metabolism: Basic Concepts and Design

15. Signal-Transduction Pathways: An Introduction to Information Metabolism

16. Glycolysis and Gluconeogenesis

17. The Citric Acid Cycle

18. Oxidative Phosphorylation

19. The Light Reactions of Photosynthesis

20. The Calvin Cycle and the Pentose Phosphate Pathway

21. Glycogen Metabolism

22. Fatty Acid Metabolism

23. Protein Turnover and Amino Acid Catabolism

III. Synthesizing the Molecules of Life

24. The Biosynthesis of Amino Acids

25. Nucleotide Biosynthesis

26. The Biosynthesis of Membrane Lipids and Steroids

27. DNA Replication, Recombination, and Repair

28. RNA Synthesis and Splicing

29. Protein Synthesis

30. The Integration of Metabolism

31. The Control of Gene Expression

IV. Responding to Environmental Changes

32. Sensory Systems

33. The Immune System

34. Molecular Motors

Appendix A: Physical Constants and Conversion of Units

Appendix B: Acidity Constants

Appendix C: Standard Bond Lengths

Glossary of Compounds

Answers to Problems

Common Abbreviations in Biochemistry